ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Seminal ribonuclease

Intermolecular
Cysteine 57 and cysteine 58
Intramolecular
Cysteine 91 and cysteine 98
A redox-regulated disulphide may form between two units of Seminal ribonuclease at cysteines 57 and 58 (31 and 32 respectively in this structure).

Details

Redox score ?
82
PDB code
1bsr
Structure name
bovine seminal ribonuclease structure at 1
Structure deposition date
1993-04-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Seminal ribonuclease
Peptide B name
Seminal ribonuclease
Peptide A accession
P00669
Peptide B accession
P00669
Peptide A residue number
57
Peptide B residue number
58

Ligandability

Cysteine 57 of Seminal ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Seminal ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Seminal ribonuclease between cysteines 91 and 98 (65 and 72 respectively in this structure).

Details

Redox score ?
87
PDB code
1r5d
Structure name
x-ray structure of bovine seminal ribonuclease swapping dimer from a new crystal form
Structure deposition date
2003-10-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00669
Residue number A
91
Residue number B
98
Peptide name
Seminal ribonuclease

Ligandability

Cysteine 91 of Seminal ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Seminal ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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